How High Doses of Ibuprofen May Impact Male Infertility

How High Doses of Ibuprofen May Impact Male Infertility

How High Doses of Ibuprofen May Impact Male Infertility

Scientists analyzed the hormones and blood of a group of 31 healthy white men between 18 and 35 years old over the course of six weeks.

However, for men, it could compromise their ability to procreate, a new study suggests.

There are new concerns that men who take a lot of Ibuprofen could face fertility problems.

Ibuprofen belongs to a group of drugs called non-steroidal anti-inflammatories, or NSAIDs, that work by blocking the production of hormone-like signaling molecules called prostaglandins, which theoretically reduces pain and inflammation.

Participants were split into two groups, with 14 receiving 600mg of ibuprofen twice a day two weeks before and 30 days after an exercise session, and the other acting as a control.

It has already been linked with fertility problems in women taking the drug. The condition, generally associated with elderly men and linked to reproductive and physical disorders, including infertility, results in the body having higher levels of luteinizing hormone (LH) than testosterone. The painkiller users could potentially face prolonged low testosterone levels after the body loses its ability to compensate, leading to a host of health conditions including muscle weakness and loss, low fertility, and other issues.

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While the study sample was a relatively small one, the researchers noted that its findings have been independently confirmed from isolated cells, and earlier studies had suggested potential issues with men's sexual health and the drug.

Common brands of ibuprofen include Advil and Motrin. "It is also associated with depression and increased risk for cardiovascular events, including heart failure and stroke".

Previous research by European scientists showed that male babies whose mothers took ibuprofen experienced disturbances to their endocrine system, according to CNN.

This is a problem, as the function of LH is to stimulate the production of testosterone, and not to significantly surpass testosterone levels. 17 men were given a daily dose of 1200mg if ibuprofen. In both cases, ibuprofen had a direct effect on the testicles.

Again, it's important to emphasize this was a really small study that required two weeks of constant ibuprofen use before there was any indication that something was out of the ordinary.

On a positive note, the disorder remains totally reversible when the ibuprofen is taken over a brief period, Bernard Jégou, a co-author at French National Institute of Health and Medical Research, told CNN.

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